Random Thoughts – Randocity!

Should I get vaccinated for COVID-19?

Posted in advice, COVID-19, virus by commorancy on December 10, 2020

This is a very good question, but the answer may not be as simple as you think. Let’s explore.

COVID-19 Pandemic

COVID-19 is clearly the news of the year. It is a virus with an approximate 6% mortality rate for at-risk individuals. What that means is that for every 100 people infected, around 6 people will die from contracting it. That’s a 94% survival rate. While 6% seems low, it’s high when considering the number of people infected so far. By comparison, let’s consider that the Flu’s mortality rate is about 0.1 percent. To see one death to Influenza would take 1000 infections.

Let’s consider that there are around 330 million people in the United States. We’ll go with this number for calculations, but the population of the United States may now be closer to 350 million people as of 2020. Let’s consider that 2% of 330 million is 6.6 million deaths and 6% is 19.8 million deaths. If the range of mortality swings from 2% to 6%, that’s somewhere more than 6 million and less than 20 million dead due to COVID-19 if the majority of the United States population becomes infected. That’s a lot of dead people… way more than from Influenza and colds combined.

COVID-19 was identified by China on December 31st, 2019 to the World Health Organization. However, the virus may have been in circulation as early as mid-November 2019. This means that the virus could have been circulating the globe since late November 2019.


As of this article, COVID-19 has claimed the lives of nearly 290,000 people in the United States. Compared against the reported number of infections of 15.5 million, that’s an approximate 1.9% mortality rate. That may seem lower than the 6% high, but that’s partly because hospitals have had time to reduce the mortality rate under their care. It’s also that during the summer into fall, those who tested positive were younger adults whose survival rate is much higher than older adults and those at risk.

Unfortunately, the Spring statistics when the virus first appeared showed the mortality rate much closer to that 6% number than it is today. There are many reasons for this change, but suffice it to say that survival of the virus isn’t going up specifically. It’s that the age (and survival rate) of those infected during the summer have skewed the numbers of dead in a lower direction. Though, medical workers have also had some time to help work through better treatment options which may have had some impact on survival in some cases, including the use of Remdesivir. The only way to know the true mortality rate is for the virus to spread through the entire population of the U.S. before we can really know the survivability statistics.


One other way to alter the survivability is by developing a vaccine that can help our susceptible and fragile human bodies build up immunity to this virus before exposure. To that end, pharmaceutical companies are hard at work fast tracking human vaccines that have been tested (albeit with limited trials) for their effectiveness.

Unfortunately, fast tracking a drug through the United States system is fraught with peril. Most drugs go through years of many clinical trials and FDA approval processes before being allowed to be sold within the United States. This is the way the FDA works. Years of clinical trials ensures that each drug’s side effects are mostly documented and known. Fast tracking a vaccine through the system means that while the efficacy of the drug may be somewhat proven, the long term side effects have not at all been tested. Long term testing of side effects cannot happen when a drug maker has a few months to formulate a product and a few weeks to test it.

Side Effects

What all of this means is that these vaccines may have unintended side effects that could appear weeks, months or even years later. In fact, these long term effects could lead to cancer or any number of other deadly diseases or medical conditions. These vaccines are simply untested and unknown how far or deep these unintended side effects may go.

Sure, it’s great that a rushed vaccine may (or may not) produce an immunity to COVID-19 (we’ll come to this point in another section below), but at the cost of what future medical reality? Do you really want to be the first to jump out of a sinking boat into another sinking boat simply because it looks like it isn’t?

This isn’t saying the COVID-19 vaccines aren’t effective. They may very well be. But, we also don’t know what else may come to those who cannot wait. If you take the vaccine and then a month later develop a nerve disorder, then what? The damage has already been done. You can’t un-vaccinate yourself. Once you take the vaccine, it’s a done deal. The cards fall where they may. If that means that you become debilitated by a separate disease, then you’re stuck with that choice for the rest of your life.

Waiting Game

What I’m stating is that this is a game of wait and see. What I mean is that we’ve waited this long for a vaccine, we can wait a little longer. Being the first person to have that needle stuck in your arm may mean future health problems. We simply don’t know what’s in store with this vaccine.

What I’m advocating is waiting to see how the early adopters fare. Let them be the guinea pigs to inject themselves. Let those early adopters jeopardize their health first. When you’re buying an Apple product, the 1.0 version is always literally the worst version to buy. It’s never ready to go day one. The same exists for this vaccine.

Can it get worse?

After all of the above, it can still get worse. Considering that the vaccines for COVID-19 currently being formulated are explicitly designed to trigger an immune system response, there’s always a danger. First, it could trigger the wrong response in the body. The below documentary describes a clinical trial for an immuno-mucking drug which ultimately led to a Cytokine Storm in almost every trial participant, which in-turn nearly killed every participant in the trial. If the trial had been performed in any place other than in a very large hospital under hospital auspices, the trial may have been lethal.

Second, consider that when taking this vaccine, you’re likely to leave that medical facility the very same day without any further monitoring. You’re going to head home or back to work or out shopping immediately. If your body spirals into a cytokine storm half an hour after taking the vaccine, it could be fatal before you ever reach a hospital. You won’t be at a hospital for them to notice and treat you. Even then, hospital staff aren’t likely to determine that it’s a cytokine storm reaction. Instead, they’re likely to admit you under the guise of COVID-19 and then treat you as if you have COVID-19… that even assumes that with the overcrowding of hospitals to COVID-19, that you can even be admitted and treated. If the hospital misdiagnoses the cytokine storm, it could be fatal. Even respected journals have published theories discussing cytokine storms as a possible outcome from a COVID-19 infection. In fact, it is supposed that many of the deaths from COVID-19 may, in fact, be because of a cytokine storm.

If an adverse reaction occurs after taking a COVID-19 vaccine, the hospitals may not have any beds to treat you. Yet a third reason why it may not be a great idea to take the vaccine during this hospital overcrowding situation. Considering the unknowns surrounding these vaccines, it may be medically wise to consider all options, including waiting to take the vaccine until a time when hospitals are far less crowded.

You don’t want to be first in-line and then end up in the hospital hours later clinging to life because your body’s immune response has overreacted to the vaccine and your organs are shutting down.

Realities, Theories and Promises

It’s always wise to consider all options before you jump into anything that requires poking a needle into your arm. Anything that is something you haven’t taken before is always a risk. These vaccines are particularly at risk because not only were they rushed to market, not only were they not fully clinically trialed, not only does this vaccine muck with immune system responses, not only does it claim efficacy, it may not even work as promised and may have unknown side effects.

The theories surrounding the method of action for these vaccines is that these vaccines are designed to elicit the same immuno-response as COVID-19 in the body. That’s the theory (and the promise). If the formulations are off, if the quality control is suspect, if the manufacturer can’t replicate the vaccine properly, if the vaccine is improperly stored, it can lead to all sorts of complications. This is the reason it’s important to consider all options before being stuck with a needle.

You don’t want to find out that your body rejects the vaccine and now you’re in a life or death struggle. But, that’s an immediate response. What about long term responses? We simply don’t know what those are. The vaccine companies and doctors are espousing exactly how “safe” these vaccines are, but they’re speaking out of turn. In reality, they have no idea how safe or effective these vaccines actually are.

Even if the best case is that the vaccine does exactly what it claims (and there’s a chance it won’t on at least some percentage of the population), it may turn out that the vaccine’s effects only lasts for 3 or 4 months. That’s effectively the same as wearing SPF in the sun where you have to reapply it every 30 minutes. Yes, SPF works, but at the cost of constantly reapplying it. Same for this vaccine. Unless a vaccine lasts for years, it’s not really a vaccine. It’s a drug. If you’re required to re-administer this “drug” every 2 months, that’s not really a useful product. Worse, you’ll end up exposing yourself to this drug every 2 months which increases the risk of short and long term side effects with each dose.

We simply don’t know how long this “vaccine” lasts. Taking this shot every 60 days is really not an option. I’m sure the pharmaceutical companies would love this for money making purposes, but heading to the doctor’s office for constant shots is not an option.

As a result of the rapid testing, there’s no way to know just how long the antibodies will last in the body. We could also find that in just a few months, a new strain of COVID-19 has taken hold, invalidating this “vaccine”. It’s impossible to know much about the effectiveness of this vaccine.

Risks vs Reward

Yet, CNN and other so-called “health correspondents” vigorously advocate the use of the vaccine and completely downplay all of the above concerns.

The risk with this vaccine is that it does nothing to stem the tide of COVID-19 deaths. That taking it was all for naught. We can certainly go through the charade of an ineffective vaccine, but what may come out of it is, at best, little. At worst, even more death.

We have to weigh which is more problematic, COVID-19 or the vaccine itself. I’m sure the pharmaceutical companies have formulated this vaccine with the best of intentions. We know how that proverb goes…

The road to hell is paved with good intentions.

that and Murphy’s Law

Anything that can go wrong will go wrong

Rushing to produce anything medical is fraught with unknown consequences. It is these exact unknown consequences that may very well lead us down the road to hell.

Way Down The List?

If you’re way down the list of vaccine recipients, consider yourself lucky. Those who are most at risk will be the ones who will test both Murphy’s Law and this proverb. The difficulty is that it is the front line medical workers and those most at risk earmarked for the first batches of the vaccine.

If the vaccine has consequences which are as yet unknown, complications for our front line workers could turn our hospital systems into ghost towns. If even 10% of the medical workers die as a result of unknown consequences from being vaccinated, that will leave our hospital systems unable to cope with the the mounting COVID-19 illnesses, let alone those who are ill strictly from the vaccines (see next section for more details).

These vaccines are very much an unknown risk. COVID-19 is a risk, but it is known. Which risk is better? I’ll have to let you decide. If you feel the risks of taking the vaccine are being overinflated here, then by all means go have a poke. If you’re cautious about your own body, then you may want to wait until others have jabbed themselves first. Never in the history of never has a vaccine been produced this rapidly. We just can’t know what we don’t know. Only after a first batch of vaccines have been widely disseminated and administered with few ill effects will I personally feel more confident about these vaccine risks.

That doesn’t necessarily mean the vaccine’s efficacy will fare as well as its safety record, however. The vaccine might prove to be safe and not at all risky, but how well (or long) that it is able to fend off COVID-19 has not yet been determined. For the efficacy, we will have to wait at least several months to determine.

Front Line Medical Workers and Vaccination

[Updated: 12/16/2020] Here’s a point that’s highly concerning and I thought needed more detailed discussion. Since the powers that be have decided that the front line medical workers will be the first in line to get the Pfizer vaccine, this could set the United States up for a huge future medical system failure. I can’t sugar coat this next part at all. Should an unknown medical condition rear its ugly head a month after these vaccines have been administered and incapacitate or kill many of these front line medical workers, that could leave our hospitals in a huge problematic state. As I said above, even a 10% reduction in the front line medical workers could devastate our hospital system so much so that they can no longer function.

It’s not like medical schools are ready to graduate 10% more medical students into the system who are “ready to go”. If such a problem grows way beyond 10%, then it’ll become an epic disaster. Any unforeseen problem with these vaccines could quite literally decapitate our hospital system leaving not only a disaster in this vaccine, but thousands of people without the medical care they need just as COVID-19 is ramping up to be the worst medical disaster in recent history.

Basically, if we think COVID-19 is bad now, such a vaccine failure could decimate the United States’s ability to medically handle this escalating pandemic. With such a vaccine failure, it’ll be almost impossible to foresee how much worse it will get with the loss of 10% of our front line medical workers. Let’s not even discuss the devastating blow to investors that will be laid bare on Wall Street. Considering that politicians also want to be first in line, such a vaccine failure could devastate our election and Capital Hill.

Note that the above is not intended to predict anything. In fact, these are suppositions… what if scenarios. We may find that the vaccine is perfectly safe and entirely efficacious. However, considering how rushed-to-market these vaccines are, such a vaccine failure is not at all out of the realm of possibility. In fact, simply because this failure possibility exists, I have to grit my teeth every time I see some random medical doctor on CNN or Fox News or any other news program espousing just how safe and efficacious these vaccines allegedly are. Worse, these alleged “medical professionals” completely downplay the above possibility. Even news networks which have been extremely biased towards specific politicians have completely ignored this possibility.

If I had been in charge over who gets the first vaccine doses, I would not dose every front line medical professional. Instead, I would temper that decision by giving it only to a critically short list. Any hospital professionals who are not directly in contact with COVID-19 patients should wait until we know if the vaccine has any unforeseen consequences. Dosing every front line medical worker could accidentally leave not only hospitals in the lurch, but other critical front line industries severely short on staff, like pharmacies, grocery stores and other critical industry workers.

If we think COVID-19 is bad today, a vaccine failure could take COVID-19 to a whole new level of survival… way beyond the devastation that we presently face today.


Cytokine Storm Syndrome: The Drug Trial That Went Wrong

Posted in botch, business, medical by commorancy on October 13, 2018

Here’s a story about six men, in 2006, who endured the fight for their lives after a drug trial went horribly wrong. The above program runtime is 58m 15s. Let’s explore.

Method of Action

As soon as the method of action of this drug was revealed in this documentary, my first thought was, “Uh oh”. Trying to teach the immune system to do anything is somewhat akin to attempting to steer a flood away from a town. The immune system attacks foreign invaders. That they injected this drug not knowing exactly how many receptors it might bind to was a severe “UH OH” moment before I even watched this. I already know how unpredictable the immune system can be. To intentionally try to tame the immune system to solve a medical problem is essentially playing with fire.

Too Many Mistakes

There were a number of mistakes made during this trial as well.

  • Not enough separation between patient injections
  • When reactions began to occur, the trial should have been halted until determining each injections patient’s reaction extent. Isn’t the point to document the reactions?
  • Waiting too long to determine the problem and attempt countermeasures.
  • The trial doctor was horribly uninformed of reaction possibilities
    • Because doctor was uninformed of side effects, the facilities were ill prepared to handle what came after
    • Not enough drugs or equipment handy to handle medical complications

Trial Paradigm Failure?

The 10 minute separation between the patients was far too quick a succession, particularly when you’re screwing with the immune system, to fully understand how the drug might react. When the first patient began experiencing problems, the trial should have halted further injections to assess the already injected patients. This trial simply threw caution to the wind and endangered all of its trial participants even when they had huge red warning flags from patient 001.

That the doctor wasn’t self-informed on the possible reactions and had to spend valuable time to seek information later, “Wow”. If that’s not the very definition of uninformed, I don’t know what is. Before a single vial was injected, the doctor should read and understood each and every possible manufacturer side effect including having enough known remedies handy. You can’t know what you don’t know, but you can know what is written down by the manufacturer. Not reading and comprehending that literature fully before starting the trial is a huge mistake. If he had fully understood the ramifications of cytokine storm syndrome before injecting a single patient, he could have had started countermeasures much, much sooner in these patients.

If he wasn’t proficient in cytokine storm syndrome, he should have had a doctor on standby should the patients need another opinion.

The almost fatal mistake here was the attending doctor bought fully into the hype of the manufacturer that “nothing bad” would happen after injection. That’s called taking things for granted. Trial drugs are experimental for a reason and must be treated with all of the seriousness and respect they deserve.

Patient Trials

While it’s critically important to trial medicines in humans, it’s equally important to perform those trials in as safe a manner as humanly possible. This includes performing these trials in facilities capable of handling the load of every patient in the trial potentially crashing. If there’s not enough equipment in the hospital facility to handle that number of simultaneous crashes, then the trial needs to be moved to a hospital that can handle this patient load.

No trial clinic should be waiting for ambulances, equipment and medicines to arrive from around the city. All of this should be immediately on-hand, ready and waiting. To me, that’s a huge failing of the company that scheduled this trial. That company should definitely be held accountable for any problems that arise from being ill prepared at its clinic facilities.

Cytokine Storm Syndrome

One of the possible side effects after the doctor read the manufacturer’s literature of the trial drug TGN-1412 was a cytokine storm. He only read this after the trial had started and patients were already suffering. Cytokine storm is when the body’s immune system reacts systemically over the whole body. It can cause basically rapid shutdown of organs including fever, nausea, redness (heat) because the body’s immune system is attacking… well basically everything. That this reaction was fully documented in the drug’s literature is telling. It says that the manufacturer knew this was a possible complication, yet the trial doctor didn’t look at this literature until it was nearly too late.

Of course, by that time other doctors had been consulted in the midst of crashing patients, these other doctors felt the need throw their own wrenches into the works by claiming the drug itself may have been tainted or improperly stored, prepared or handled… possibly causing these patients to have an systemic infection. Throwing this wrench into the works was also reckless by those additional doctors who joined in on the action. Perhaps they needed to also ready the manufacturer’s literature before jumping to that conclusion.

It’s good that someone finally decided the correct course of action was to treat for cytokine storm as the manufacturer’s reactions suggest, but not before one of the trial patients had ended up with dry gangrene losing his fingertips and parts of his feet. A horrible ending to a drug trial that was ill prepared and improperly staffed for that kind of a drug reaction.


I know it’s easy to both see and say all of this in hindsight. But, I have worked at many companies where the all mighty buck is rules… basically, “Do it for as cheaply as possible”. The saying, “You get what you pay for” applies in every situation. I’ve worked for many organizations that blaze ahead with projects without fully evaluating all consequences of their actions. They do this simply because they want the product out the door fast for the least amount of money. They don’t care what problems might arise. Instead, they deal with the problems along the way. If that means throwing more money at it later, so be it. Just don’t spend it now.

To me, that’s reckless. Thankfully, I have never worked for a medical organization at all. I’ve chosen to stay away from that line of work for the simple reasons of what this level of recklessness can do when put into the hands of medical organizations. This trial should be considered the very definition of reckless and what can happen when the all mighty buck is more important than patient’s lives. Thankfully, the NHS stepped in on behalf of the patients and treated them as the sick patients they were, not guinea pig trial participants.

I encourage you to watch the program in full. Then please leave a comment below if you agree or disagree.


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